Next generation sequencing of the tumor at baseline showed microsatellite instability high (loss of MLH1 and PMS2 and TMB 15, ARID1A G801FS*32, KRAS Q6H, PIK3CA N1044K, PTEN R130G, SMARCA4 P109FS*194 and SMARCA4 P316FS*10 mutations). This evidence concerns the gene PIK3CA and neoplasm.