Three DLTs were experienced by 2 patients treated with AZD7648 20 mg BID 28 days + PLD 40 mg/m2 (grade 3 neutropenia and grade 4 neutropenia with grade 4 stomatitis) and one patient treated with AZD7648 30 mg QD 7 days + PLD 40 mg/m2 (grade 3 increased ALT). The gene discussed is GPT; the disease is neutropenia.