METTL13 and acute myeloid leukemia: To further explore the functional roles of METTL13 in AML progression, we knocked down METTL13 (METTL13-KD) using lentivirus expressing short hairpin RNA (shRNA) targeting METTL13 (shMETTL13#1 and shMETTL13#2) in HL-60 and K562 cell lines (Fig. 2A and B).