Of particular interest, MMP-10 is induced in all kidney fibrosis models tested, such as UUO, UIRI, FAN, db/db mice, and Ang II-infusion, as well as in human kidney biopsies from patients with various CKD, such as IgA nephrology, diabetic nephrology and lupus nephritis (Fig. 1). This evidence concerns the gene MMP10 and chronic kidney disease.