IL6 and Alzheimer disease: This goes align with the restriction impact of PD98059 on IL-6, NF-κB in an atopic dermatitis model (Yu et al. 2021), beside other studies documented the neuroprotective effect of PD98059 against BACE-1 expression in human SH-SY5Y neuroblastoma (Harrison et al. 2007) as well as Aβ precipitation (Rapoport and Ferreira 2000) in models of AD.