Furthermore, neuroinflammation plays role in AD pathology via the generation of various inflammatory markers such as nuclear factor-kappa B (NF-κB) which activates interleukin-6 (IL-6) that promotes further release of different pro-inflammatory cytokines resulting in the synthesis of inflammatory mediators in an endless cycle (Wang et al. 2003). The gene discussed is NFKB1; the disease is Alzheimer disease.