GSK3B and ischemic stroke: These were in comply with those studies that showed the influence of lithium, as GSK-3β inhibitor, on neuroblastoma SH-SY5Y human cells (Grimes and Jope 2001; Mai et al. 2002) as well as its effect in vivo and invitro in models of ischemic stroke induced excitotoxicity (Chuang et al. 2011).