ACHE and Alzheimer disease: Likewise, aromatic ring of coumarins can attach to AchE, thereby blocking the development of Aβ-AchE conjugates as well as possessing BACE-1 inhibiting activity in comply with an in in vitro study that discussed the potential of coumarins to combat against AD focusing on the structure-activity analysis (Ali et al. 2016), so it may show promising effect against AD.