Furthermore, ERK1/2 phosphorylation inhibition by STZ + PD98059 group may participate in AD amelioration which may be supported by an in vitro study used hippocampal slice cultures of male Wistar rats to report that ERK1/2 activation is observed shortly following the lack of oxygen and glucose in CA1 and CA3 of hippocampus. This evidence concerns the gene MAPK3 and Alzheimer disease.