By integrating single-cell clustering data, eQTL, pQTL data, and GWAS data for colorectal cancer, we conducted two-sample Mendelian randomization and SMR analyses, identifying statistically significant associations between changes in the expression levels of four genes (CTSF, PCSK7, LYZ, LMAN2L) and susceptibility to CRC. Here, CTSF is linked to colorectal cancer.