By combining single-cell analysis, eQTL analysis, pQTL analysis, and SMR analysis, we have identified four potential disease targets (CTSF, PCSK7, LYZ, LMAN2L), providing new potential targets and ideas for the development of gene and protein regulation-related drugs for CRC, which is of great significance for improving the prevention, diagnosis, and treatment of colorectal cancer. Here, LYZ is linked to colorectal cancer.