LYZ and colorectal carcinoma: By integrating single-cell clustering data, eQTL, pQTL data, and GWAS data for colorectal cancer, we conducted two-sample Mendelian randomization and SMR analyses, identifying statistically significant associations between changes in the expression levels of four genes (CTSF, PCSK7, LYZ, LMAN2L) and susceptibility to CRC.