KCNQ2-associated epilepsies encompass a wide spectrum of epilepsy syndromes, including self-limited early-onset epilepsies (where seizure remission is seen in the majority of affected children [56]), and KCNQ2-DEE (where seizure freedom is not uncommon by adolescence or early adulthood [104]). The gene discussed is KCNQ2; the disease is developmental and epileptic encephalopathy.