Of note, siRNA-mediated knockdown of CSTF2 or ADAR1 in MCF7 cells did not result in a noticeable reduction of MDM2 transcript levels and there was no correlation between ADAR1 and MDM2 mRNAs levels in the TCGA breast cancer RNA-seq data for LumA patients (Fig. S7). The gene discussed is ADAR; the disease is breast cancer.