Immunohistochemical staining further revealed increased expressions of COL10A1 and TPPP3 in fibrotic niches in advanced NASH tissues, which is consistent with their putative roles in extracellular matrix (ECM) remodeling and macrophage-mediated fibrogenesis (Figure 5D andSupplementary Figure S6D). This evidence concerns the gene COL10A1 and metabolic dysfunction-associated steatohepatitis.