Through multiomics integration of scRNA-seq, histopathological evaluation, and transcriptional profiling of murine and human NASH tissues, we demonstrated that CD24+LCN2+ LPCs orchestrate ductular proliferation and TPPP3+COL10A1+ macrophage activation, thereby amplifying hepatic fibrogenesis through proinflammatory and fibrogenic crosstalk. The gene discussed is LCN2; the disease is metabolic dysfunction-associated steatohepatitis.