Immunohistochemical staining further revealed increased expressions of COL10A1 and TPPP3 in fibrotic niches in advanced NASH tissues, which is consistent with their putative roles in extracellular matrix (ECM) remodeling and macrophage-mediated fibrogenesis (Figure 5D andSupplementary Figure S6D). The gene discussed is TPPP3; the disease is metabolic dysfunction-associated steatohepatitis.