We found that resident LCN2+CD24+ LPCs were activated in NASH and that the macrophage subset closely communicating with resident LCN2+CD24+ LPCs highly expressed the fibrosis-related genes tubulin polymerization promoting protein family member 3 (TPPP3) and collagen type X alpha 1 chain (COL10A1). Here, CD24 is linked to metabolic dysfunction-associated steatohepatitis.