CDI due to the ribotype 027 strain was independently associated with prior macrolide or fluoroquinolone exposure, decreased functional capability, methicillin-resistant Staphylococcus aureus nasal colonization, age >65 years, white blood cell count >11,000 cells/mm3, and serum albumin < 3.5 g/dl. This evidence concerns the gene ALB and clostridium difficile infection.