Most of the overall 208 genes differentially expressed in CHB and co-regulated in our ATAC-seq/RNA-seq were shared (n = 167) between the different CHB categories whereas 24 were unique to CH group (HBe pos CH and HBe neg CH) and 17 exclusives of the HBe neg CI patients (Fig. 8a). Here, HBE1 is linked to cyclic hematopoiesis.