Specifically, the infiltration of TREM-1 + TAMs in HCC were shown to mediate hypoxia-induced tumor immunosuppression and resistance to anti-PD-L1 therapy, by recruiting CCR6 + Foxp3 + Treg cells via the CCL20/ERK/NF-κB pathway [199]. This evidence concerns the gene CD274 and hepatocellular carcinoma.