Similarly, it has been proven that oxidative stress caused by alanine-serine-cysteine transporter 2 (ASCT2) deletion leads to the unregulated release of exosomal THBS1 from oral squamous cell carcinoma cells [121], which activates p38, Akt, and SAPK/JNK signaling and favor M1-like differentiation [122]. The gene discussed is SLC1A5; the disease is oral cavity squamous cell carcinoma.