For example, Nicoletta et al. performed single-cell RNA-sequencing (scRNA-seq) on PDAC biopsies from cancer patients and revealed that inflammatory IL-1β + TAMs were shown to co-express both inflammatory (MHCII, CD80 and CD86) and immune inhibitory markers (CD206, arg-1 and PD-L1) [43]. This evidence concerns the gene CD274 and cancer.