It is widely acknowledged that chemokines secreted by tumor cells such as CCL2, CCL5, CCL7, CCL20, CXCL2, CXCL8 and CXCL12 [15, 26–28] significantly contribute to the recruitment of monocytes and macrophages during neoplastic transformation, among which CCL2 plays a key role in TAM recruitment. This evidence concerns the gene CXCL12 and neoplasm.