CD4 and malaria: However, among PLHIV, the risk of malaria treatment failure (unadjusted for recrudescence or reinfection) on day 45 was found to be 2.24-fold higher among those with CD4 cell count < 300 cells/μL compared to those with CD4 cell count ≥ 300 cells/μL (RR 2.24, 95%CI 1.20–4.17, p-value = 0.01).