Emergence of SARS-CoV-2 variants is of great concern as it can lead to immune escape, but majority, of SARS-CoV-2-specific CD4+ T cells (93%) and of CD8+ T-cell (97%) in naturally infected or Pfizer/BioNTech and Moderna COVID-19 mRNA vaccinated individuals are conserved across variants including Alpha, Beta and Gamma strains39. This evidence concerns the gene CD4 and COVID-19.