Previous research has indicated a decrease in insulin-like growth factor 1(IGF-1) levels in obese children15,16, with reduced IGF-1 levels independently correlated with various cardiovascular risk factors such as nonalcoholic fatty liver disease (NAFLD)17, insulin resistance18, low high density lipoprotein cholesterol (HDL-C)15, and metabolic syndrome(MS)15. The gene discussed is IGF1; the disease is metabolic dysfunction-associated steatotic liver disease.