ITGAE and neoplasm: Here, we develop a cascade antigen relay strategy based on the integration of antigen-capturing nanoparticles (AC-NPs) and migratory CD103+ type 1 conventional dendritic cells (cDC1s), which we refer to as Antigen-Capturing nanoparticle Transformed Dendritic Cell therapy (ACT-DC), for effective in situ immunization and remodeling of the tumor microenvironment.