TGFB1 and rheumatoid arthritis: The expression level of FN1 is positively correlated with transforming growth factor beta (TGF-β) activity, and TGF-β, due to its pivotal role in joint destruction, is considered a crucial target for monitoring disease progression and developing therapeutic strategies.106 In summary, Vickovic et al. constructed a fused morphological 3D spatial transcriptome landscape of synovial tissue from RA patients (Fig. 2d).