The study revealed that in the draining lymph nodes of late-stage arthritis, close crosstalk between ALCAM+ macrophages and CD6 + T cells promoted B cell differentiation into plasma cells and IgG2b+ class switching.100 The aggregation of IgG2b+ plasma cells near the MARCO+ sinusoids in the draining lymph nodes was associated with the exacerbation of late-stage arthritis.100 The findings of Kenney et al. further deepen our understanding of the relationship between arthritis progression and lymphatic dysfunction. This evidence concerns the gene CD6 and arthritic joint disease.