NT5E and neoplasm: Their study, augmented by multiplex immunofluorescence staining, found CD73+ Ewing’s sarcoma cells exhibited similarities with CAFs in upregulating extracellular matrix protein expression and deposition, and they, therefore, categorized this subgroup as CAF-like tumor cells.150 Their findings underscore the significant role of CAF-like tumor cells in remodeling the TME to promote tumor initiation and progression.150