The outcomes showed that SREBP1 is the main binding protein involved in the function of MARCH8. Although MARCH8 appears to be highly expressed in HCC tissues than in normal tissues in the TCGA database [52], this does not contradict the current findings, as the TCGA database comprises transcriptome data from HCC patients rather than protein expression level data. The gene discussed is SREBF1; the disease is hepatocellular carcinoma.