FASN and hepatocellular carcinoma: The results of this study demonstrate that MARCH8 significantly inhibits lipid accumulation and HCC progression by suppressing the expression of ACC1 and FASN through the K48-associated ubiquitination-mediated degradation of SREBP1. However, this study also showed that the TR2 domain of MARCH8 can bind to the LC2 domain of SREBP1, which in turn promotes its ubiquitination and consequent degradation.