Additionally, expression of IFN-γ, GZMB and TNF-α was found to be enhanced in CD8+CD160+ T cells relative to CD8+CD160− T cells (Fig. 8D), indicating a potential proinflammatory and cytotoxic role of SG CD8+CD160+ T cells in the pathogenesis of pSS. This evidence concerns the gene CD8A and peeling skin syndrome.