Moreover, several single nucleotide polymorphisms (SNPs) at the SNCA locus, highly associated with increased risk for PD in GWAS, correlated with higher levels of α-synuclein in the cerebrospinal fluid of patients [16], or higher mRNA levels in the SN [17] or frontal cortex [18] of human post-mortem tissue, as well as in human induced pluripotent stem cells [19]. The gene discussed is SNCA; the disease is Parkinson disease.