Studies have reported the accumulation of P4HA2 in cancer cells and its contribution in accelerating collagen deposition and metastatic dissemination in vivo, such as lung adenocarcinoma [12], hepatocellular carcinoma [13], prostate cancer [14], cervical cancer [15], glioblastoma [16] and so on. Here, P4HA2 is linked to Familial prostate cancer.