Animal studies using SCID/Beige, injected with low-NDRG1 expressing or high-NDRG1 MDA-IBC3 inflammatory breast cancer cells, demonstrated increased brain metastasis, greater tumor burden, and reduced survival in mice injected with high-NDRG1 expressing cells compared to their low-NDRG1 expressing counterparts (19). This evidence concerns the gene NDRG1 and breast cancer.