In addition, proteins involved in the drug resistance phenotype, including P-glycoprotein (Pgp; ABCB1), low-density lipoprotein receptor-related protein 1 (LRP1), and multidrug resistance-associated protein 1 (MRP1; ABCC1), were also increased in NDRG1 overexpressing cells, further suggesting an NDRG1-mediated role in multidrug resistance of neuroblastoma (251). This evidence concerns the gene LRP1 and neuroblastoma.