NDRG1 and neoplasm: For instance, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) and di-2-pyridylketone-4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) have been extensively shown to upregulate NDRG1 expression, leading to metastasis suppression and inhibition of tumor growth in multiple cancer models.