This yielded a final list of three candidate genes: ANKLE2, PAFAH1B1, and WEE1. ANKLE2 has previously been reported as a promoter of tamoxifen resistance in breast cancer cells, and WEE1 has been extensively studied as a therapeutic target across multiple cancer types, including breast (12, 13, 14). The gene discussed is PAFAH1B1; the disease is breast carcinoma.