EXO1 and Friedreich ataxia: The volcano map depicts the differential correlationcoefficients for the Fanconi anemia (FA) pathway and cell-cycle-relatedgenes (Figure b).The FA pathway is a replication-coupled DNA repair mechanism thatis known to enlist several key proteins involved in homologous recombination. Given that, under normal physiology, EXO1 activityis restricted to DNA replication and is known to functionally intersectwith FA and cell cycle genes, it was unsurprising to see that thesepathways were the most highly correlated with EXO1 expression.