EXO1 and cancer: Given that cancer cells havean increased reliance on EXO1 to counteract stress due to abnormaland overactive DNA replication processes, small molecules targetingEXO1 represent a major opportunity to specifically kill cancer cellsby targeting aberrant replication-associated repair systems, particularlyin human breast cancer and other hormone-dependent cancers that bearan increased burden of replication stress due to heightened hormonesignaling.,