PBRM1 is a chromatin modulator of the SWI/SNF chromatin remodeling complex, which includes SMARCA4, SMARCB1, SMARCC1, ARID1A, DPF2, and SMARCE1, also implicated in ACE2 expression regulation and, thus, in host cell susceptibility to viral infection (63). The gene discussed is SMARCC1; the disease is viral infectious disease.