PBRM1 is a chromatin modulator of the SWI/SNF chromatin remodeling complex, which includes SMARCA4, SMARCB1, SMARCC1, ARID1A, DPF2, and SMARCE1, also implicated in ACE2 expression regulation and, thus, in host cell susceptibility to viral infection (63). This evidence concerns the gene SMARCA4 and viral infectious disease.