PIK3C3 and infection: In a chemical screen for host cell kinases required for S. flexneri dissemination, we identified seven potent compounds, including the class III phosphatidylinositol 3-phosphate kinase (PIK3C3) inhibitor VPS34-IN1 (S1 Table), that decreased the size of the infection foci formed by S. flexneri in HT-29 cells.