Interestingly, while beta amyloid plaques are present in the aging human brain, and are especially prominent in human Alzheimer’s disease (AD) and in mouse AD models, there is relatively little amyloid plaque development in the human and mouse retina [16–18], despite high concentrations of soluble amyloid precursor protein [19]; reviewed in Wang et al [20]]. The gene discussed is APP; the disease is Alzheimer disease.