AGT and aneurysm: No obvious aneurysms were observed in WT and AAV9-SM22/Telokin-ABE–treated ACTA2R179H/+ mice after Ang II infusion; one saline-treated ACTA2R179H/+ mouse (1 out of 4) exhibited an obvious aneurysm throughout the thoracic and abdominal aorta, accompanied by thrombus formation, after 2 weeks of Ang II infusion (Figure S10B).