For the first, second, and third component, the brain tumor methylation classifier (v12.8) calculated scores of 0.99, 0.99, and 0.79 for the “pituitary adenoma” methylation classes “subtype STH producing, subclass sparsely granulated”, “subtype ACTH producing”, and “subtype gonadotrophin producing”, respectively. Here, POMC is linked to pituitary gland adenoma.