Overall, Tx intake did not relevantly affect loss variance, with P = .53 (2.57, 95% CI [−5.51 dB2; 10.66 dB2]) in the univariable analysis and P = .44 (0.03, 95% CI [−0.05 dB2; 0.10 dB2]) in the multivariate analysis (with further independent variables: age, diabetes mellitus, other aromatase inhibitors). Here, CYP19A1 is linked to diabetes mellitus.