In the multivariable analysis, the effect of aromatase inhibitors showed a small, estimated decline in visual acuity of 0.098 logMAR (95% CI [0.004 logMAR units; 0.193 logMAR units]; P-value of.041; other independent variables in the model: Tx, age, diabetes mellitus). The gene discussed is CYP19A1; the disease is diabetes mellitus.