An FM causes early onset neurodevelopmental fragile X syndrome (FXS), while PM is linked to many fragile X-associated conditions (FXPAC) including fragile X-associated tremor/ataxia syndrome (FXTAS), fragile X-associated primary ovarian insufficiency (FXPOI), and fragile X-associated neuropsychiatric disorders (FXAND). Here, PSMB5 is linked to fragile X-associated tremor/ataxia syndrome.