ACE and Hyponatremia: All types of antihypertensive medications, with the exception of loop diuretics, were associated with an increased the risk of hyponatraemia, with thiazides and thiazide-like diuretics (SHR 1.47, 95% CI 1.45–1.49), ACE inhibitors (SHR 1.35, 95% CI 1.34–1.37) and ARBs (SHR: 1.30, 95% CI 1.27–1.33) conferring the highest risks (Table 2).