This effect wasalso demonstrated for the human nei-like DNA glycosylase 3 (NEIL3)promoter region. Additionally, the oxidationof VEGF was found to affect recognition by nucleolinand influenced the G4 topology. In thecontext of a duplex-G4-duplex motif, the major VEGF G4 appears to exhibit accelerated folding kinetics in response toDNA damage. Given the significance ofG4 structures in genomic stability and transcriptional regulation,elucidating their role in DNA repair and damage recognition has directimplications for cancer therapeutics. The gene discussed is VEGFA; the disease is cancer.