Nevertheless, an elevated level of Nrf2 has also been linked to tumor suppression, as reported by Shao et al., that an upregulation of Nrf2 and GSH (glutathione) expression using curcumin leads to efficient ROS scavenging, reduction in VEGF generation, and ultimately a reduction in hepatocarcinoma aggressiveness [64]. This evidence concerns the gene VEGFA and neoplasm.