AKT1 and neoplasm: Moreover, the drug Curaxin CBL0137, a regulator of p53 and NF‐ĸB, was also reported as a potent inhibitor of B‐cell non‐Hodgkin's lymphoma tumor growth, and it functioned by triggering ROS generation that led to the activation of the P13K/Akt/mTOR and MAPK signaling pathways, eventually causing cell apoptosis and autophagy [112].