The present investigation sought to elucidate three fundamental aspects: the temporal dynamics of ferroptosis following cerebral ischemia, the therapeutic potential of atVNS to mitigate ferroptosis and enhance neurological recovery during chronic post‐stroke periods, and the mechanistic role of α7nAChR in mediating the neuroprotective effects of atVNS. This evidence concerns the gene CHRNA7 and Cerebral ischemia.