developed an O2 self‐supplying PFOB@TA‐Fe(III)‐LOX nanoplatform (PTFL, tannic acid (TA)–Fe(III) coordination complexes‐coated perfluorooctyl bromide (PFOB) nanodroplets with lactate oxidases (LOX) loading) to achieve PAI‐guided cascade metabolic chemokinetic therapy.[260] By synergistically consuming ATP and lactate while generating hydroxyl radicals, this platform achieves enhanced antitumor efficacy by simultaneously disrupting tumor metabolism and oxidative stress induction. The gene discussed is LOX; the disease is neoplasm.