MAPT and Alzheimer disease: developed a neuron‐targeting multifunctional nanocomposite integrating tannic acid (TA)‐based nanoparticles with manganese ions, IR780 dye, and TPL peptide (IR780‐Mn@TA‐TPL) for MRI/FLI‐guided AD therapy.[369] The nanocomposite exploited the antioxidant properties of tannic acid for ROS scavenging and tau pathology inhibition, while TPL peptide enhanced BBB penetration and neuron‐specific targeting.