established a pancreatic cancer‐specific phototheranostic modulator (AuHQ) that combines AIEgens‐tethered AuNPs with enzyme‐responsive peptides for FLI/PAI‐guided PTT/immunotherapy (Figure 12e).[300] AuHQ is engineered to respond to the pancreatic tumor microenvironment by utilizing the peptide AGFSLPAGC, which is cleaved by the enzyme Cathepsin E (CTSE), prevalent in pancreatic cancer. This evidence concerns the gene CTSE and pancreatic neoplasm.