further advanced this approach with Au@Ag core‐shell nanoparticles with double‐layer Raman reporters for triple‐biomarker (EGFR, ErbB2, IGF1) detection.[249] In vivo investigations using xenotransplanted tumor models validated the efficacy of this platform in monitoring therapeutic responses to tamoxifen treatment and surgical intervention. The gene discussed is ERBB2; the disease is neoplasm.