ERBB2 and breast carcinoma: engineered a targeted SERS imaging platform for intraoperative guidance and microscopic tumor elimination to improve breast‐conserving surgery outcomes.[253] The platform utilized gold nanostar‐based probes (AuSt cores) encapsulated with Raman reporters and silica shells, functionalized with HER2‐targeting nucleic acid aptamers for specific targeting of HER2+ breast cancer (Figure 8b).