Furthermore, morphometric covariance properties, compared to other Alzheimer’s disease biomarkers such as total GM volume, CSF total tau and MMSE scores, appeared to better predict hippocampal atrophy rates.46 Interestingly, the above-mentioned traditional biomarkers showed no association with individual rates of hippocampal atrophy, suggesting that network properties may better capture changes during very early preclinical stages. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.