Besides, a negative correlation has been reported between tau-retention, clustering coefficient and node degree in the posterior cingulate, inferior parietal lobule and precuneus in Alzheimer’s disease patients compared to cognitively preserved, age-matched healthy controls.47 Additionally, tau-PET retention has been reported to be related to greater GM network disruption in individuals across the Alzheimer’s disease continuum,48 more evident with increasing disease severity and tau load. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.