Compared with the tumor tissue, a denser and more complex association network was formed in the adjacent non-tumor tissue of ESCC.88,89 Most differential abundances in adjacent non-tumor tissues were negatively associated with the epidermal growth factor receptor, erb-b2 receptor tyrosine kinase 2, erb-b2 receptor tyrosine kinase 4, and fibroblast growth factor receptor 1 signaling pathways. Here, FGFR1 is linked to neoplasm.