These tumors are well exemplified by hematolymphoid and CNS tumors, such as acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1‐RUNX1T1, myeloid/lymphoid neoplasms with PDGFRA rearrangement, diffuse midline glioma, H3 K27‐altered, CNS tumor with BCOR internal tandem duplication, and so on. The gene discussed is RUNX1; the disease is central nervous system neoplasm.