LAMB2 and neoplasm: It is composed of a specific matrix, enriched with hyaluronic acid and lower levels of collagens and laminins, along with tumor and immune cells, with MACs being the predominant immune cell population in glioblastoma.30–33 These cells secrete cytokines that inhibit immune responses, promoting tumor growth and CAR-T-cell impedance.25 Additionally, the TME of brain tumors is enriched with neurons and oligodendrocytes, which also support tumor progression.34 Pericytes and astrocytes further strengthen the BBB by encircling endothelial cells.