ERBB2 and neoplasm: Bone-marrow-derived MACs (BMDMs) expressing first-generation anti-HER2 CARs enhanced CAR-MAC-mediated tumor cell phagocytosis and pro-inflammatory cytokine secretion following stimulation with LPS and recombinant mouse IFNγ.74 Intravenous infusion of the previously mentioned M1 polarized CAR-MACs in an ovarian cancer model, a lung metastasis model, and a subcutaneous melanoma model led to enhanced suppression of tumor growth compared to unstimulated CAR-MACs.