Moreover, radiotherapy combined with CD47 blockade induces a macrophage-mediated abscopal effect, where MACs enhance tumor clearance both at the irradiated site and in target distant, non-irradiated tumors.70 This highlights the potential for radiotherapy, alongside CD47 inhibition, to further boost the antitumor efficacy of CAR-MAC therapies. Here, CD47 is linked to neoplasm.