PIEZO1 and osteoarthritis: Multiple studies have shown the therapeutic benefits of intra-articular administration of Gsmtx4 in treating OA, the mechanisms encompass the inhibition of Piezo1-mediated cartilage apoptosis, the Piezo1 channel facilitates calcium influx, inducing GPX4-regulated chondrocyte ferroptosis in osteoarthritis, and other pathological manifestations (Wang et al., 2022; Ren et al., 2023).