In contrast, M2 macrophages have important roles in regulating anti-inflammatory responses, promoting wound healing, and expressing pro-tumor properties (33).M2 macrophages, stimulated by IL-4 and IL-13, secrete IL-10, TGF-β, and chemokines, which are involved in the remodeling of the tumor stroma and promote angiogenesis and tumor cell infiltration, thereby accelerating tumor progression (34, 35). This evidence concerns the gene IL13 and neoplasm.