A recent study identified tectonic family member 1 (TCTN1) as a critical regulator of Fatty Acid Oxidation (FAO) in melanoma, promoting both tumor invasiveness and metastatic potential facilitating the interaction between HADHA and HADHB, subunits of the mitochondrial trifunctional protein (MTP) complex, which catalyzes FAO. The gene discussed is TCTN1; the disease is melanoma.