The presence of stromal cells increased the transcription of matrix remodeling proteins (FN1 and MMP9) and the release of tumor-promoting immune molecules such as macrophage inhibitory factor (MIF), Serpin E1, chemokine (C-X-C motif) ligand 1 (CXCL1), interleukin-8 (IL-8) and chemokine (C-X-C motif) ligand 12 (CXCL12). The gene discussed is CXCL12; the disease is neoplasm.