CRC is related to environmental factors (e.g., smoking, diet, obesity, alcohol), immune system dysregulation, or genetics, such as mutations of microsatellite instability (MSI) genes MSH1, MLH1, and MSH6, adenomatous polyposis coli (APC), or nucleotide-binding oligomerization domain 2 (NOD2) (Lawes et al., 2005). This evidence concerns the gene NOD2 and obesity disorder.