In one study, a 3D multicellular model for CRC was constructed using the CRC cell line SW480 with CAFs and endothelial cells, showing improved expression of several tumor-related genes including IL1B, FCGR2A, FCGR3A, CYBB, SPI1, CCL2, ITGAM, and ITGB2 (Wang et al., 2023). Here, IL1B is linked to colorectal carcinoma.