CD274 and neoplasm: Due to the dynamic interactions between these antibodies and the immune microenvironment and the variability of the immune environment in different tumor types, the predictability of PD-L1 expression remains uncertain and contradictory (Burtness et al., 2019; Doroshow et al., 2021; Topalian et al., 2012; Shen and Zhao, 2018; Yu et al., 2019).