SPP1 and hepatocellular carcinoma: In our study, we successfully developed a prognostic signature comprising 16 SPP1+ TAMs-related genes (FCGR2B, CAPNS1, C11orf58, NDUFA8, CD37, SRI, KYNU, UBE2I, TFPT, PSMC6, CALM3, DDT, NME1, RABAC1, GTF2H5, CDC42), which demonstrated the potential to predict OS in patients with HCC.