MAPT and Brain atrophy: The amyloid cascade hypothesis, one of the most promising proposals, points the accumulation of the beta-amyloid protein in plaques as the initial event on the AD pathogenesis, which in addition to the deposition of Tau neurofibrillary tangles, promotes neuronal death and progressive synaptic dysfunction, leading to brain atrophy seen in advanced stages of the disease(Scheltens et al., 2021).