Notably, the R47H missense mutation in triggering receptor expressed on myeloid cells 2 (TREM2) has been shown to significantly increase the risk of AD, with an odds ratio comparable to that of the APOE ε4 allele (Qin et al., 2021; Silvin et al., 2022; Ulland et al., 2017; Zhao et al., 2022c). The gene discussed is TREM2; the disease is Alzheimer disease.