The synergy of anti-dsDNA antibody-mediated immune complex formation and classical complement activation, along with immune cell infiltration, release of chemokines, cytokines, and proteolytic enzymes, and oxidative damage, can induce kidney inflammation and subsequent organ damage (47); (2) activated leukocyte cell adhesion molecule (ALCAM, also named as CD166) is a cell adhesion glycoprotein expressed on antigen-presenting cells that mediates immune cell adhesion and migration, co-stimulation of T cells, and sustains T-cell activation. The gene discussed is ALCAM; the disease is nephritis.