Due to the different regions in the identification of high and low hypoxia levels in the models, and the TME analysis based on TCGA transcriptome data, it was also suggested that the hypoxia level in tumor tissue was negatively correlated with the level of CD8+ T cell infiltration in the TME in various tumors, including PDAC (Supplementary Figure S4). The gene discussed is CD8A; the disease is neoplasm.