reported that tumor-derived lactate fuels H3K18 lactylation prohibited RARγ transcription in macrophages, consequently enhancing IL-6 levels in the TME and endowing macrophages with tumor-promoting functions via activation of signal transducer and activator of transcription 3 (STAT3) signaling in colorectal cancer cells (61). The gene discussed is RARG; the disease is neoplasm.