IL10 and neoplasm: Additionally, M2-type TAMs exert immunosuppressive effects in the tumor microenvironment by secreting a series of cytokines and chemokines, as described below: IL-10 is a key immunosuppressive cytokine, which inhibits the activation of dendritic cells and T cells, suppresses the production of pro-inflammatory cytokines, and promotes the differentiation of regulatory T cells (Tregs), leading to immune evasion.